Forging Literary History: Historical Fiction and Literary Forgery in Eighteenth-Century Britain

In this essay, I wish to explore a similar dialectic of historical positivism and skepticism in eighteenth-century Britain. Over the course of the century, but particularly in the second half, new and more scientific standards of historical investigation developed, with practitioners expressing a greater confidence about their ability to know the past. During these years, a series of monumental achievements in historiography appeared: David Hume’s History of England (1754–62), Edward Gibbon’s Decline and Fall of the Roman Empire (1776), and William Robertson’s History of Scotland (1759), to name just three of the most celebrated. As part of this increased interest in the past and increased optimism about the ability to understand earlier historical periods, a range of new types of writing about the past proliferated, such as antiquarian studies, social and cultural history, literary history, universal history, and conjectural history. While the study of history was developing much more rigorous standards of investigation and historical works were among the bestselling titles of the century, a strain of historical skepticism was gaining force, often finding expression in the writings of the very same people who were doing the confident historical investigation. This philosophical skepticism is perhaps most dramatically illustrated in the writings of major historians such as Hume and Robertson. The works of these philosophical historians were steeped in skepticism about both individual historical details and the possibility of achieving any kind of historical certainty

Tales of Other Times: A Survey of British Historical Fiction 1770-1812

The years 1760–1820 mark a turning point in the history of historiography. Methods for studying the past changed rapidly during this period, as did the forms in which historical knowledge was displayed. Hume famously called these years ‘the historical age’, while Foucault’s Order of Things contends that an epistemic shift from ‘order’ to ‘history’ took place around the year 1800. The historical novel, possibly the most important generic innovation of Romantic-era fiction, is also the most important and underexplored historiographic innovation of these years. Its importance has not often been recognised, however, since, following the nineteenth-century establishment of an autonomous realm of art and the professionalisation of historiography, history and fiction came to appear more and more distinct and their earlier connections forgotten. The novel has come to be studied as a linguistically complex work of the imagination, using the techniques of close reading to uncover its hidden meanings, while works of historiography have more often been studied for the ideas they express than their means of expression

The Footnote, in Theory

And, so, when Richard Stern published his private dialogue with himself about the physical appearance of certain writers at the 1986 International PEN conference, Joyce Carol Oates insisted on not only an angry rebuttal-punctuated by constant page referencing to Stern\u27s pig-souled sexism -but photographic evidence-a kind of footnote in itself-dismissing his physical characterization of her. When Susan Gubar published What Ails Feminist Criticism? her essay provoked an immediate, critical, and heavily documented response from Robyn Weigman, several letters to the editor, and Gubar\u27s own footnoted rejoinder. Jane Gallop\u27s defense of a sexual act she engaged in with one of her students and Paul de Man\u27s controversial writings in a Belgian newspaper in the thirties (which, incidentally, resulted in a marked decline in the number of times he was cited in our pages) generated similar feelings of anger, disgust, and betrayal, all accompanied by footnotes. This journal, in fact, argues that passion is not diminished when it is superscripted. In point of fact this apparent function may nearly always be associated with such diverse functions as the manifestation of relations of allegiance or dependence, of strategies of affiliation, of annexation or of defence (this is the role, for example, of guarantee references, ostentatious references or alibi-references)

Invasive Group A Streptococcal Disease: Risk Factors for Adults

We conducted a case-control study to identify risk factors for invasive group A streptococcal (GAS) infections, which can be fatal. Case-patients were identified when Streptoccus pyogenes was isolated from a normally sterile site and control subjects (two or more) were identified and matched to case-patients by using sequential-digit telephone dialing. All participants were noninstitutionalized surveillance area residents, >18 years of age. Conditional logistic regression identified the risk factors for invasive GAS infection: in adults 18 to 44 years of age, exposure to one or more children with sore throats (relative risk [RR]=4.93, p=0.02), HIV infection (RR =15.01, p=0.04), and history of injecting drug use (RR=14.71, p=0.003); in adults >45 years of age, number of persons in the home (RR=2.68, p=0.004), diabetes (RR= 2.27, p=0.03), cardiac disease (RR=3.24, p=0.006), cancer (RR= 3.54, p=0.006), and corticosteroid use (RR=5.18, p=0.03). Thus, host and environmental factors increased the risk for invasive GAS disease

What Is the Value of Wild Bee Pollination for Wild Blueberries and Cranberries, and Who Values It?

Pollinator conservation efforts and growing interest in wild bee pollination have increased markedly in the last decade, making it increasingly important to have clear and practical estimates of the value of pollinators to agriculture. We used agricultural statistics, socio-economic producer surveys, and agronomic field research data to estimate traditional pollination value metrics and create novel approaches to the valuation of the ecosystem services provided by wild pollinators. Using two regionally important United States (USA) crops—Maine wild blueberry and Massachusetts cranberry—as models, we present the perceived values of wild bee pollinators from the perspectives of both consumers and producers. The net income attributable to wild bees was similar for wild blueberry ($613/ha) and cranberry ($689/ha). Marginal profit from incrementally adding more hives per ha was greater from stocking a third/fourth hive for cranberry ($6206/ha) than stocking a ninth/10th hive for wild blueberry ($556/ha), given the greater initial responsiveness of yield, revenue, and profit using rented honey bee hives in cranberry compared with wild blueberry. Both crops’ producers were willing to annually invest only $140–188/ha in wild pollination enhancements on their farms, justifying government financial support. Consumers are willing to pay ≈6.7 times more to support wild bees than producers, which indicates a potential source for market-based subsidies for invertebrate conservation

Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor

Glucocorticoid (GC) receptors (GRs) have profound anti-survival effects on human small cell lung cancer (SCLC). To explore the basis of these effects, protein partners for GRs were sought using a yeast two-hybrid screen. We discovered a novel gene, FAM33A, subsequently identified as a SKA1 partner and involved in mitosis, and so renamed Ska2. We produced an anti-peptide antibody that specifically recognized full-length human SKA2 to measure expression in human cell lines and tissues. There was a wide variation in expression across multiple cell lines, but none was detected in the liver cell line HepG2. A xenograft model of human SCLC had intense staining and archival tissue revealed SKA2 in several human lung and breast tumours. SKA2 was found in the cytoplasm, where it co-localized with GR, but nuclear expression of SKA2 was seen in breast tumours. SKA2 overexpression increased GC transactivation in HepG2 cells while SKA2 knockdown in A549 human lung epithelial cells decreased transactivation and prevented dexamethasone inhibition of proliferation. GC treatment decreased SKA2 protein levels in A549 cells, as did Staurosporine, phorbol ester and trichostatin A; all agents that inhibit cell proliferation. Overexpression of SKA2 potentiated the proliferative response to IGF-I exposure, and knockdown with shRNA caused cells to arrest in mitosis. SKA2 has recently been identified in HeLa S3 cells as part of a complex, which is critical for spindle checkpoint silencing and exit from mitosis. Our new data show involvement in cell proliferation and GC signalling, with implications for understanding how GCs impact on cell fate

Measurement of Epstein-Barr virus DNA load using a novel quantification standard containing two EBV DNA targets and SYBR Green I dye

<p>Abstract</p> <p>Background</p> <p>Reactivation of Epstein-Barr virus (EBV) infection may cause serious, life-threatening complications in immunocompromised individuals. EBV DNA is often detected in EBV-associated disease states, with viral load believed to be a reflection of virus activity. Two separate real-time quantitative polymerase chain reaction (QPCR) assays using SYBR Green I dye and a single quantification standard containing two EBV genes, Epstein-Barr nuclear antigen-1 (EBNA-1) and BamHI fragment H rightward open reading frame-1 (BHRF-1), were developed to detect and measure absolute EBV DNA load in patients with various EBV-associated diseases. EBV DNA loads and viral capsid antigen (VCA) IgG antibody titres were also quantified on a population sample.</p> <p>Results</p> <p>EBV DNA was measurable in ethylenediaminetetraacetic acid (EDTA) whole blood, peripheral blood mononuclear cells (PBMCs), plasma and cerebrospinal fluid (CSF) samples. EBV DNA loads were detectable from 8.0 × 10²to 1.3 × 10⁸copies/ml in post-transplant lymphoproliferative disease (n = 5), 1.5 × 10³to 2.0 × 10⁵copies/ml in infectious mononucleosis (n = 7), 7.5 × 10⁴to 1.1 × 10⁵copies/ml in EBV-associated haemophagocytic syndrome (n = 1), 2.0 × 10²to 5.6 × 10³copies/ml in HIV-infected patients (n = 12), and 2.0 × 10²to 9.1 × 10⁴copies/ml in the population sample (n = 218). EBNA-1 and BHRF-1 DNA were detected in 11.0% and 21.6% of the population sample respectively. There was a modest correlation between VCA IgG antibody titre and BHRF-1 DNA load (rho = 0.13, p = 0.05) but not EBNA-1 DNA load (rho = 0.11, p = 0.11).</p> <p>Conclusion</p> <p>Two sensitive and specific real-time PCR assays using SYBR Green I dye and a single quantification standard containing two EBV DNA targets, were developed for the detection and measurement of EBV DNA load in a variety of clinical samples. These assays have application in the investigation of EBV-related illnesses in immunocompromised individuals.</p

Development of a Novel Renal Activity Index of Lupus Nephritis in Children and Young Adults

OBJECTIVE: Noninvasive estimation of the degree of inflammation seen on kidney biopsy with lupus nephritis (LN) remains difficult. The objective of this study was to develop a Renal Activity Index for Lupus (RAIL) that, based solely on laboratory measures, accurately reflects histologic LN activity. METHODS: We assayed traditional LN laboratory tests and 16 urine biomarkers (UBMs) in children (n = 47) at the time of kidney biopsy. Histologic LN activity was measured by the National Institutes of Health activity index (NIH-AI) and the tubulointerstitial activity index (TIAI). High LN-activity status (versus moderate/low) was defined as NIH-AI scores >10 (versus ≤10) or TIAI scores >5 (versus ≤5). RAIL algorithms that predicted LN-activity status for both NIH-AI and TIAI were derived by stepwise multivariate logistic regression, considering traditional biomarkers and UBMs as candidate components. The accuracy of the RAIL for discriminating by LN-activity status was determined. RESULTS: The differential excretion of 6 UBMs (neutrophil gelatinase-associated lipocalin, monocyte chemotactic protein 1, ceruloplasmin, adiponectin, hemopexin, and kidney injury molecule 1) standardized by urine creatinine was considered in the RAIL. These UBMs predicted LN-activity (NIH-AI) status with >92% accuracy and LN-activity (TIAI) status with >80% accuracy. RAIL accuracy was minimally influenced by concomitant LN damage. Accuracies between 71% and 85% were achieved without standardization of the UBMs. The strength of these UBMs to reflect LN-activity status was confirmed by principal component and linear discriminant analyses. CONCLUSION: The RAIL is a robust and highly accurate noninvasive measure of LN activity. The measurement properties of the RAIL, which reflect the degree of inflammatory changes as seen on kidney biopsy, will require independent validation

Conceptualizing handover strategies at change of shift in the emergency department: a grounded theory study

<p>Abstract</p> <p>Background</p> <p>The importance and complexity of handovers is well-established. Progress for intervening in the emergency department change of shift handovers may be hampered by lack of a conceptual framework. The objectives were to gain a better understanding of strategies used for change of shift handovers in an emergency care setting and to further expand current understanding and conceptualizations.</p> <p>Methods</p> <p>Observations, open-ended questions and interviews about handover strategies were collected at a Veteran's Health Administration Medical Center in the United States. All relevant staff in the emergency department was observed; 31 completed open-ended surveys; 10 completed in-depth interviews. The main variables of interest were strategies used for handovers at change of shift and obstacles to smooth handovers.</p> <p>Results</p> <p>Of 21 previously identified strategies, 8 were used consistently, 4 were never used, and 9 were used occasionally. Our data support ten additional strategies. Four agent types and 6 phases of the process were identified via grounded theory analysis. Six general themes or clusters emerged covering factors that intersect to define the degree of handover smoothness.</p> <p>Conclusion</p> <p>Including phases and agents in conceptualizations of handovers can help target interventions to improve patient safety. The conceptual model also clarifies unique handover considerations for the emergency department setting.</p